Common Genetic Variation and Human Traits in NEJM
April 28, 2009
A commentary from David Goldstein at Duke University provides an interpretation and perspective on how best to interpret and utilise data from recent experiments linking human disease and related traits to genetic variation. The April 23, 2009 publication in the New England Journal of Medicine argues the scientific community needs to build on the common variant data with much more extensive investigation of rare variants.
Genomewide Association Studies and Human Disease in NEJM
April 20, 2009
In a recent review article in the New England Journal of Medicine, John Hardy and Andrew Singleton provide an excellent overview of the concepts linking genetic variability with observed phenotypes and the methods, such as genome wide association studies and sequencing, for analysing such variability. The focus is on the genetic causes of human disease but the principles discussed are much more general.